October 24, 2018

Bioengineering (Systems Biotechnology)

This nobel research area studies biological systems (humans, bacteria and even fungus) as a whole, trying to understand their function not only from it’s separated particles, but the complete genome, giving a more systemic approach.

This glance takes different parts of the biological system, such as genes, transcribed proteins and metabolites, and analyzes how do they impact and determine their phenotype, and how they are connected in networks of inhibition or cooperation. In the study of biological processes, the classical scientific method is used, which is based on the confirmation or refutation of an hypothesis when confronted with experimental results.

Systemic Biology uses a different approach, based on the mathematical modeling of the processes under study. As a result of the simulation, the mathematical models with which the process is represented, scientists can obtain a series of predictions of the state of biological processes that would correspond to the expected experimental results.

Systems Biotechnology uses this information to create products that can benefit society. These products can come from microorganisms, bacteria and yeast in order to create bioplastic, biofuel, proteins, and even nanoparticles.

In this matter, the research done in CBIB is based on the environmental bacteria Pseudomonas putida, and its metabolic versatility.

The Center has worked in the sequence of these pseudomonas, find their capabilities and create models to predict and create new biopolymers, with carbon sources and residues that had never been used before. One of the main projects developed in this matter by CBIB is based on Synthetic Biology. The aim of this revolutionary work is to synthesize genes for the creation of a self-destructive bacteria to eventually transform regular plastic in bioplastic.