July 1, 2019

Chemical Synthesis

Yorley Andrea Duarte

Research Profesor


Our research group focuses on the search and rational design of new molecules that inhibit or modulate the function of various membrane or cytosolic proteins. At the same time, we have the tools and knowledge of Chemical Synthesis to obtain and modify Leading Molecules with the aim of improving their affinity and biological activity against a particular target. Using chemical synthesis, we develop new controlled drug release systems, using nanotechnology and systems that involve this technology.
Our research group collaborates constantly with other groups involving new chemical strategies oriented to give solutions in pharmacology, microbiology, agronomy and medicine.


Novel Coumarin-Quinoline Hybrids: Design of Multitarget
Compounds for Alzheimer’s Disease
Yorley Duarte, André Fonseca, Margarita Gutiérrez, Francisco Adasme-Carreño,
Camila Muñoz-Gutierrez, Jans Alzate-Morales, Lourdes Santana, Eugenio Uriarte,
Rocío Álvarez, and Maria João Matos.
Chemistry Select https://doi.org/10.1002/slct.201803222. 2019
Integration of target discovery, drug discovery and drug delivery: A review on computational strategiesYorley Duarte Q , Valeria Márquez-Miranda, Matthieu J. Miossec , Fernando González-NiloWires Nanomed Nanobiotechnol.. 2019 . doi.org/10.1002/wnan.1554
Experimental and Theoretical Approaches in the Study of Phenanthroline‐Tetrahydroquinolines for Alzheimer's DiseaseDr. Yorley Duarte Dr. Margarita Gutierrez Dr. Rocío Álvarez Dr. Jans H. Alzate‐Morales Dr. Jorge Soto‐DelgadoChemistry Open. 2019. doi.org/10.1002/open.201900073