April 27, 2016

Nanomedicine and Targeted Delivery Lab

Cristian Vilos

Research Professor  

Dr. Cristian Vilos is a Faculty Member of the Center for Integrative Medicine and Innovative Science (CIMIS) at the Faculty of Medicine, and also is a Principal Investigator at the Center for Bioinformatics and Integrative Biology (CBIB) in the Faculty of Biological Sciences at Andres Bello University. Dr. Vilos did his undergraduate studies in Medical Technology at the University of Talca, and later did his Ph.D. in Biotechnology at the University of Santiago in Chile, where started to work in drug delivery systems based on biodegradable and biocompatible polymers.

Dr. Vilos was Visiting Professor and Postdoctoral Fellow at the Laboratory of Nanomedicine and Biomaterials at Department of Anesthesia at Brigham and Women’s Hospital (BWH) and Harvard Medical School (HMS). He also was a member of Langer Lab at David H. Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology (MIT) between 2013-2015.

Currently, Dr. Vilos is focused on the development of combined drug therapy based polymeric nanoparticles for colorectal cancer, advanced nanotherapies for chronic pain, as well as, the study of fundamentals of nano-bio interactions in the physiological environment. More at www.viloslab.com

Lines of research

  • Polymeric Nanoparticles as Therapeutic Platforms
  • Drug Delivery based on Microparticles Technology
  • Novel Biomaterials for Nanotherapeutics





109Nanotechnology and primary hemostasis: Differential effects of nanoparticles on platelet responses.Matus MF,  Vilos C , Cisterna BA, Fuentes E, Palomo I.Vascular Pharmacology. 2017. DOI: 10.1016/j.vph.2017.11.004.
106Bioinspired Heparin Nanosponge Prepared by Photo-crosslinking for Controlled Release of Growth Factors.Choi WI, Sahu A, Vilos C , Kamaly N, Jo SM, Lee JH, Tae G. Scientific Reports. 2017. DOI: 10.1038/s41598-017-14040-5.
84Intracellular trafficking and cellular uptake mechanism of PHBV nanoparticles for targeted delivery in epithelial cell lines.Penaloza, JP.; Marquez-Miranda, V.; Cabana-Brunod, M.; Reyes-Ramirez, R.; Llancalahuen, FM.; Vilos, C.; Maldonado-Biermann, F.; Velasquez, LA.; Fuentes, JA.; Gonzalez-Nilo, FD. ; Rodriguez-Diaz, M.; Otero, C.Journal of Nanobiotechnology. 2017. DOI: 10.1186/s12951-016-0241-6
82Antiplatelet effect of differentially charged PEGylated lipid-polymer nanoparticles.E Fuentes, B Yameen, SJ Bong, C Salvador-Morales, I Palomo, C Vilos .Nanomedicine: Nanotechnology, Biology and Medicine. 2017. DOI: 10.1016/j.nano.2016.10.010
81Proteína Morfogenética Ósea y su Opción como Tratamiento de la Fisura Alveolar.F Uribe, M Cantín, JP Alister, C Vilos , R Fariña, S Olate.International Journal of Morphology. 2017. DOI: 10.4067/S0717-95022017000100049
80Targeted brain delivery nanoparticles for malignant gliomas.MP Pinto, M Arce, B Yameen, C Vilos .Nanomedicine. 2017. DOI 10.2217/nnm-2016-0307
79Optimization of fibrin gelation for enhanced cell seeding and proliferation in regenerative medicine applications.WI Choi, B Yameen, C Vilos , A Sahu, SM Jo, D Sung, G Tae.Polymers for Advanced Technologies.2017. DOI 10.2217/nnm-2016-0307


61Mechanistic Studies on the Self-Assembly of PLGA Patchy Particles and Their Potential Applications in Biomedical ImagingC. Salvador-Morales, Binal Brahmbhatt, V. Márquez-Miranda, I. Araya-Duran, J. Canan, F. Gonzalez-Nilo, C. Vilos,  J. Cebral, F. Mut, R. Lohner, B. Leong, G. Sundaresan, and J. Zweit.Langmuir. 2016. DOI: 10.1021/acs.langmuir.6b02177.
52Targeted nanoparticles for colorectal cancer
Cisterna, BA.; Kamaly, N.; Choi, WI.; Tavakkoli, A.; Farokhzad, OC.; Vilos, C.Nanomedicine. 2016. DOI: 10.2217/nnm-2016-0194
51Techniques of Structural Characterization of DendrimersLizama, OV.; Vilos, C.; Duran-Lara, E.Current Organic Chemeistry. 2016. DOI:10.2174/1385272820666160608095009.
39Chitosan functionalized thermosponge nano-carriers for prolonged retention and local delivery of chymopapain at the nucleus pulposus in porcine discs ex vivoChoi, WI.; Sahu, A.; Vilos, C.; Lee, JH.; Kim, S.; Hong, YK.; Sul, D.; Hwang, SW.; Lee, SH.; Tae, G.RSC Advances. 2016. DOI: 10.1039/c6ra17848k.
38Mechanistic Studies on the Self-Assembly of PLGA Patchy Particles and Their Potential Applications in Biomedical ImagingSalvador-Morales, C.; Brahmbhatt, B.; Marquez-Miranda, V.; Araya-Duran, I.; Canan, J.; Gonzalez-Nilo, F.; Vilos, C.; Cebral, J.; Mut, F.; Lohner, R.; Leong, B.; Sundaresan, G.; Zweit, J.LANGMUIR. DOI: 10.1021/acs.langmuir.6b02177.
37Optimization of fibrin gelation for enhanced cell seeding and proliferation in regenerative medicine applicationsWon Il Choi, Basit Yameen2, Cristian Vilos, Abhishek Sahu, Seong-Min Jo, Daekyung Sung, Giyoong Tae.Polymers for Advanced Technologies. 2016. DOI: 10.1002/pat.3866.









Book Chapter

  1. Chapter 10: Stimuli-Responsive Nanotheranostics. Basit Yameen, Jun Wu, Cristian Vilos, Andrew Whyte, David Werstler, Lori Pollit , Omid C. Farokhzad. Nanotheranostics for Personalized Medicine: 267-296. World Scientific, 2016.

Patent Applications

  • Constandil L., Ibarra P., Vilos C., Veláquez L., Pelissier T., Laurido C., Hernández A. Nanoparticles With Biodegradable and Biocompatible Polymer PLGA, Loaded With the Drug for Human Use Pentoxifylline. Publication number: WO2014075203 A8 – PCT number: PCT/CL2013/000084 – Also published as: WO2014075203A8.
  • Shi J., Zeyu X., Votruba A., Vilos C., Farokhzad O. Lipid-polymer hybrid particles. Publication number: US20130315831 A1 – Application number: US 13/820,351 – PCT number: PCT/US2011/050334 – Also published as: WO2012031205A2, WO2012031205A3.
  • Vilos C., Velásquez L. A., Orihuela P., Rios M. Injectable veterinary composition for sustained release of ceftiofur and florfenicol in animal species, which comprises poly(lacticcoglycolic acid) (plga) microparticles, and the method for the preparation thereof. Publication number: WO2013071456 A3 – Application number: PCT/CL2012/000066 – Also published as: WO2013071456A2.
  • Vilos C.Velásquez LA., Constandil L., Rios M. Injectable veterinary composition for controlled, sustained release of ceftiofur and florfenicol in animal species, based on polyhydroxybutyrate hydroxyvalerate (phbv) microparticles.  Publication number: WO2013071457 A1 – Application number: PCT/CL2012/000067 – Also published as WO2013071457A4.

Funding | Current Research Support

  • FONDECYT Regular #1161438 (2016–2018), [Principal Investigator]

  • UNAB Regular, DI-695-15/R (2015–2016), [Principal Investigator]

  • Basal Grant FB0807, (NanoBioMedicine L6) CEDENNA – CONICYT (2015 – 2019), [Young Research]